Therapeutics Resources Directory
A curated directory of resources including links to webinars, guidance documents, databases and additional tools – explore key themes from discovery through to regulatory approval.
Last updated: August 2026
Disclaimer: PACE is not responsible for the content of the external materials or websites referenced. The directory has been compiled to provide a curated list of publicly available resources intended to support antimicrobial R&D and project development. While care has been taken to ensure the accuracy of the information at the time of review, PACE cannot guarantee that external links will remain current or that third-party content is complete, accurate, or suitable for any specific purpose.
Resources to support antimicrobial research and development are available across a wide range of organisations’ websites and platforms. This directory brings together selected publicly available resources in one place, organised by theme, to help innovators navigate the key considerations involved in progressing an antimicrobial therapeutic from early concept through development. The resources address the practical and strategic considerations needed to progress an idea towards a viable product, from understanding clinical need and generating robust preclinical data to planning clinical translation and navigating regulatory and manufacturing requirements. The directory will continue to evolve, with additional PACE resources and relevant external materials added over time.
Resource Themes
Antimicrobial R&D Foundations
Fundamentals of antibacterial discovery — targets, resistance, hit-to-lead and lead optimisation.
Clinical Positioning & Developing a Target Product Profile
Target Product Profiles, clinical positioning and prioritising unmet needs.
ADME
Absorption, Distribution, Metabolism and Excretion — in vitro and in vivo profiling.
Toxicology & Safety Assessment
Cytotoxicity, safety pharmacology, NOAEL and GLP-| compliant toxicology.
In Vivo Models & Study Design
Infection models, ethics, translational relevance and statistical power.
Pharmacokinetics & Pharmacodynamics (PKPD)
MIC, PK/PD indices, dose selection and target attainment.
Clinical Development & Trial Planning
Trial designs, endpoints, comparator selection and breakpoint setting.
Regulatory Strategy & Planning
FDA /EMA / MHRA pathways, pre-IND, QIDP and scientific advice.
