Antimicrobial R&D Foundations

Fundamentals of antibacterial discovery — targets, resistance, hit-to-lead and lead optimisation.

Key Considerations:

• Understanding bacterial targets and resistance mechanisms
• Spectrum of activity: Gram-positive vs. Gram-negative
• Hit-to-lead and lead optimization strategies



Resources

5 resources

Webinar / Video
GARDP

An introduction to antibiotic research and development (R&D) - REVIVE

This webinar provides an introduction to the stages of this process from discovery to clinical trials and pharmaceutical development.


Webinar / Video
GARDP

Progressing an antibacterial drug discovery project – an SME perspective – REVIVE

This webinar focused on the particular challenges regarding progressing antibacterial drug discovery projects for small and medium-sized enterprises (SMEs) and their potential solutions.


Webinar / Video
GARDP

From discovery to IND: Roadmap to a successful antibacterial project – REVIVE

This session covered the full antimicrobial development journey from discovery to Phase 1, detailing strategies for hit-to-lead and preclinical candidate selection (Alita Miller) and outlining non-clinical, regulatory, and CMC requirements for first-in-human studies (Patricia Bradford).


Webinar / Video
GARDP

Progressing a discovery project - Criteria and challenges - REVIVE

This session examined Go/No-Go decision-making in antibacterial drug discovery from both industry and academic perspectives, emphasizing the role of TPPs and TCPs in guiding preclinical progression and highlighting how structured support like ENABLE helps translate academic findings into viable drug candidates.


Webinar / Video
IMI AMR Accelerator

COMBINE Webinar on Success Stories in AMR R&D

This webinar recording showcases expert-led success stories and scientific advances in novel antibiotics, including breakthroughs against multidrug-resistant Gram-negative bacteria and the development of endolysins through to human trials.



*PACE Delivery Partner Network Member: links to members with drug discovery and microbiology expertise
For introductions or further support, please contact your R&D advisor




PACE Delivery Partners

Delivery Partner Network members with expertise relevant to this theme